Programmer of a new therapeutic class of biologics called Adnectins.
Adnectins are an emerging, proprietary proteins therapeutic class that can be designed to address a broad range of diseases. They derive from human fibronectin, an extracellular protein that’s naturally loaded in human serum. The intrinsic properties of an Adnectin align with the properties needed to make a successful drug, including high potency, specificity, stability, favorable half existence, and high yield E. Coli production. Adnectins are designed using PROfusion, Adnexus’ patented protein design engine, to achieve high potency and specificity for a therapeutic focus on while simultaneously selecting for ideal pharmaceutical item characteristics.It’s estimated that nearly 15,000 Us citizens will die from esophageal tumor this year. Fifty years ago, more than 95 percent of esophageal cancers had been squamous cell – the kind caused by smoking and excess alcohol use. As smoking provides declined, the incidence of squamous cell carcinoma offers dropped. But also for reasons that aren’t clear, esophageal adenocarcinoma – the type linked to acid reflux disorder – has dramatically increased over the past forty years and now accounts for about 50 percent the instances of esophageal cancer. From 1975 to 2001 there is a 600 % rise in esophageal adenocarcinoma. The obesity epidemic may be playing a role by increasing the number of adults with acid reflux. Gastroenterologists can diagnose acid reflux disorder by slipping a slim, flexible instrument through the mouth area and down the esophagus.